Experimental Rickets in Rats on a Purified Synthetic Diet Deficient in Phosphorus and Fat-Soluble Organic Factor.

نویسنده

  • H Goldblatt
چکیده

SHERMAN and PAPPENHEIMER [1921] and later, Pappenheimer, McCann, Zucker and Hess [1921] induced the development of severe experimental rickets in rats by a diet (No. 84) consisting of 95 % patent flour and 5 % salt mixture. This diet was not only deficient in phosphorus and fat-soluble A, but was also very obviously deficient in many other respects. McCollum, Simmonds, Shipley and Park [1921], by means of diets (No. 3143 and No. 3127) composed of complex natural food substances deficient in phosphorus and the fat-soluble organic factor, also succeeded in inducing the development of severe rickets in rats. Later, McCollum, Simmonds, Becker and Shipley [1922], using diets (No. 3407 and No. 3408) composed essentially of purified food substances and deficient only in phosphorus and the fat-soluble organic factor, again succeeded in .producing severe rickets in rats. On the other hand, Korenchevsky [1921] failed to produce rickets in rats by feeding them on a purified synthetic diet, referred to as A-P diet, deficient in phosphorus and the fat-soluble organic factor. He suggests that the discrepancy between his results and that of the other authors "is no doubt due to the difference in phosphorus content in the basal diets used." But the following table shows that his A-P diet had a lower percentage of phosphorus than some of the diets of McCollum and his co-workers. In a later communication, Korenchevsky [1922] recognised this but laid emphasis on the fact that the composition of the diet in his experiments was entirely different from those of McCollum and his co-workers.

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عنوان ژورنال:
  • The Biochemical journal

دوره 18 2  شماره 

صفحات  -

تاریخ انتشار 2005